除了小分子抑制剂，核酸技术也开始在ACH治疗中得到应用。Ribomic开发的RBM-007，通过限制FGF2和FGFR3激活变体之间的过度相互作用发挥功能。2期临床结果显示，RBM-007的疗效与Vosoritide相近（1.5厘米/年），甚至有一名受试者年增长5厘米，且该试验中包括2周一次的注射频率，是当前在研药物中最长的给药间隔。
There’s a secondary pro and con to this pipeline: since the code is compiled, it avoids having to specify as many dependencies in Python itself; in this package’s case, Pillow for image manipulation in Python is optional and the Python package won’t break if Pillow changes its API. The con is that compiling the Rust code into Python wheels is difficult to automate especially for multiple OS targets: fortunately, GitHub provides runner VMs for this pipeline and a little bit of back-and-forth with Opus 4.5 created a GitHub Workflow which runs the build for all target OSes on publish, so there’s no extra effort needed on my end.
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